Methylprednisolone

Provider Level

RN/Paramedic

Class

Corticosteroid, Glucocorticoid

Mechanism of Action

Synthetic glucocorticoid that suppresses acute and chronic inflammation, alters the immune response, and potentiates vascular smooth muscle relaxation by beta-adrenergic agonists.

Indications

Severe asthma, COPD exacerbation, anaphylaxis or severe allergic reactions, adrenal insufficiency.

Contraindications

Systemic fungal infections, known hypersensitivity, premature infants.

Routes

IM, IV, IO

Onset / Duration

Onset is 1 to 2 hours. Duration is 8 to 24 hours.

Adverse Effects

Hyperglycemia, hypertension, hypokalemia, headache, sodium and water retention, gastrointestinal bleeding.

Precautions & Interactions

Use caution in patients with active gastrointestinal bleeding, diabetes mellitus, or severe hypertension.

Special Considerations

Not a first-line medication for acute allergic reactions or anaphylaxis due to its delayed onset of action. May significantly elevate blood glucose levels requiring monitoring in diabetic patients.