Loratadine

Provider Level

RN/Paramedic

Class

Second-generation antihistamine

Mechanism of Action

Selectively binds to peripheral histamine H1 receptors preventing histamine action. Does not readily cross the blood-brain barrier resulting in minimal CNS depression.

Indications

Allergic rhinitis, mild allergic reactions, chronic idiopathic urticaria.

Contraindications

Known hypersensitivity to loratadine or its components.

Routes

PO

Onset / Duration

Onset 1 to 3 hours. Duration approximately 24 hours.

Adverse Effects

Headache, fatigue, dry mouth, rare cases of somnolence.

Precautions & Interactions

Use caution in patients with severe liver impairment or renal insufficiency.

Special Considerations

Considerably less sedating than first-generation antihistamines like diphenhydramine. Not intended for the acute management of anaphylaxis as a primary agent.